Neurobiological Basis of Diseases of the Nervous System
Teaching hours and weekly schedule
This is a 2nd semester elective course of about 2.5 weeks that corresponds to 4 ECTs and 31 total hours of teaching including student presentations.
Co-ordinators
- Leonidas Stefanis
Professor of Neurology and Neurobiology, Medical School of Athens, National & Kapodistrian University of Athens
- Spiros Efthimiopoulos
Professor of Neurobiology, Department of Biology, Division of Animal & Human Physiology, National & Kapodistrian University of Athens
Description:
This is an intensive 2.5-week course focused on the Genetics, the general processes that operate in several different neurological disorders, the pathology of neurological disorders, their molecular basis, as well as experimental therapeutics. The goal of this intensive course is that students become well versed with the genetic and molecular basis of the disorders of the nervous system.
Course Overview
The course covers general principles that apply to several disorders of the nervous system as well as the description and the pathology and the molecular basis of individual diseases.
General principles include:
General principles include:
- Protein misfolding and aggregation
- protein degradation
- Inflammation
- Neurotoxic and neurotrophic pathways
Examples of the diseases of the nervous system that will be covered include:
- Alzheimer's disease
- Parkinson's disease
- Motor Neuron Disease
- Schizophrenia
- Depression
- Triple repeat disorders
- Epilepsy
- Addiction
- Nervous System Cancers
- Brain and Spinal Cord injury
Skills and Learning Outcomes
Upon successful completion of this course, students will be able to:
- Understand the common mechanisms involved in various diseases of the nervous system
- Understand the genetics of neurological diseases
- Understand and describe the molecular pathways that operate in specific disorders of the nervous system
Titles of lectures and names of the lecturers
A/A | Neurobiological Basis of Diseases of the Nervous System: | Lecturer |
1 | Neurodegenerative diseases as proteinopathies | Kostas Vekrellis |
2 | Molecular and Cellular Biology of Parkinsons’s Disease and related synucleinopathies | Leonidas Stefanis |
3 | Molecular and Cellular Biology of Alzheimer’s Disease | Spiros Efthimiopoulos |
4 | Neurodevelopmental and neuronal migration disorders of the human brain | Christina Kyrousi |
5 | Protein degradation in neurodegenerative diseases | Maria Xilouri |
6 | Mechanisms of Addiction | Styliani Vlachou, Alexia Polissidis |
7 | Brain and Spinal Cord injury | Florentia Papastefanaki |
8 | Motor Neuron Disease | Laskaro Zagoreou |
9 | Neuroprotection in neurodegenerative diseases | Dimitris Vassilatis |
10 | Molecular Basis of taupathies | Katerina Papanikolopoulou |
11 | Biomarkers of neurodegenerative diseases | Georgios Paraskevas |
12 | Cognitive functions and behavior in dementias | Sokratis Papageorgiou |
13 | Molecular Basis of taupathies | Katerina Papanikolopoulou |
14 | Life style and neurodegeneration | Nikos Scarmeas |
15 | Epilepsy | Anastasios Bonakis |
16 | Triple repeat disorders | George Koutsis |
17 | Molecular and genetic basis of schizophrenia | Alex Hatzimanolis |
18 | Cognitive deficits in schizophrenia and depression | Nikos Smyrnis |
19 | Biology of Depression | Christina Dalla, Nikolaos Kokras |
20 | Nervous System Cancers | Mimika Mangoura |
21 | Mitochondrial function and dysfunction in Alzheimer’s disease development and progression | Konstantinos Palikaras |
22 | Student Presentations | Hardy Rideout-Karadima Georgia |
